Birth & Future of Multi-scale Modeling of Macromolecules

Other Talks
Monday, November 24, 2014 - 4:30pm
2.5 hours
GT Student Center Ballroom
Stanford University

Biography: Michael Levitt is an American-British-Israeli biophysicist and professor of structural biology in
the Stanford University School of Medicine and a winner of the 2013 Nobel Prize in Chemistry. Born
in South Africa in 1947, Levitt earned his Bachelor of Science in Physics from Kings College
London and his Ph.D. in biophysics from Cambridge University. His research involves multi-scale
approaches to molecular modeling: Coarse-grained models that merge atoms to allow folding
simulation and hybrid models that combine classical and quantum mechanics to explain how enzymes
works by electrostatic strain. Levitt's diverse interests have included RNA and DNA modeling,
protein folding simulation, classification of protein folds and protein geometry, antibody
modeling, x-ray refinement, antibody humanization, side-chain geometry, torsional normal mode,
molecular dynamics in solution, secondary structure prediction, aromatic hydrogen bonds, structure
databases, and mass spectrometry. His Stanford research team currently works on protein evolution,
the crystallographic phase problem and Cryo-EM refinement. He is a member of both the Royal
Society of London and the U.S. National Academy of Science. Levitt also remains an active computer
programmer--"a craft skill of which I am particularly proud," he says.

The development multiscale models for complex chemical systems began in 1967 with publications by Warshel and Levitt recently recognized by the 2013 Nobel Committee for Chemistry. The simplifications used then at the dawn of the age of computational structural biology were mandated by computers that were almost a billion times less cost-effective than those we use today. These same multiscale models have become increasingly popular in application that range from simulation of atomic protein motion, to protein folding and explanation of enzyme catalysis. In this talk I describe the origins of computational structural biology and then go on to show some of the most exciting current and future applications. Please RSVP. Reception begins at 4:30PM; lecture starts at 5:00PM.