CANCELLED (Multi-scale Model of CRISPR-induced Coevolutionary Dynamics -- Diversification at the Interface of Lamarck and Darwin)
- Series
- Mathematical Biology Seminar
- Time
- Wednesday, November 16, 2011 - 11:00 for 1 hour (actually 50 minutes)
- Location
- Skiles 006
- Speaker
- Lauren Childs – Biology, Georgia Tech
The CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) system is a recently discovered immune defense in bacteria and archaea (hosts) that functions via directed incorporation of viral DNA intohost genomes. Here, we introduce a multi-scale model of dynamic coevolution between hosts and viruses in an ecological context that incorporates CRISPR immunity principles. We analyze the model to test whether and how CRISPR immunity induces host and viral diversification and maintenance of coexisting strains. We show that hosts and viruses coevolve to form highly diverse communities through punctuated replacement of extant strains. The populations have very low similarity over long time scales. However overshort time scales, we observe evolutionary dynamics consistent with incomplete selective sweeps of novel strains, recurrence of previously rare strains, and sweeps of coalitions of dominant host strains with identical phenotypes but different genotypes. Our explicit eco-evolutionary model of CRISPR immunity can help guide efforts to understand the drivers of diversity seen in microbial communities where CRISPR systems are active.