The Spatio-Temporal Dynamics of Synthetic Microbial Consortia

Mathematical Biology Seminar
Wednesday, April 20, 2022 - 10:00am for 1 hour (actually 50 minutes)
Krešimir Josić – University of Houston –
Bo Lin

Please Note: Meeting Link: (Meeting ID: 948 8229 0086, Passcode: 264830)

Modeling is essential in the design of genetic circuits with desired properties. I will review several examples where mathematical models have been central to the development and understanding of the dynamic of synthetic organisms. I will start with a discussion of synthetic bacterial consortia that exhibit emergent oscillatory behavior - when co-cultured, the interaction between two bacterial strains results in population-level transcriptional oscillations. The spatio-temporal dynamics of such consortia, including synchrony between distant parts of the population, depend sensitively on the architecture of the underlying genetic circuits. I will then describe how oscillations, and other spatiotemporal patterns can arise in consortia of cells that individually exhibit bistable dynamics. I will show how simplified mathematical models can help us understand how order emerges in these system, how robust oscillations and other patterns can arise, and how they are maintained.