Georgia Institute of Technology College of Sciences

Mathematical modeling, analysis and numerical simulation, combined with imagingand experimental validation, provide a powerful tool for studying various aspects ofcardiovascular treatment and diagnosis. At the same time, problems motivated bycardiovascular applications give rise to mathematical problems whose studyrequires the development of sophisticated mathematical techniques. This talk willaddress two examples where such a synergy led to novel mathematical results anddirections. The first example concerns a mathematical study of the benchmarkproblem of fluid‐structure interaction (FSI) in blood flow. The resulting problem is anonlinear moving‐boundary problem coupling the flow of a viscous, incompressiblefluid with the motion of a linearly viscoelastic membrane/shell. An existence resultfor an effective, reduced model will be presented.The second example concerns a novel dimension reduction/multi‐scale approach tomodeling of endovascular stents as 3D meshes of 1D curved rods. The resultingmodel is in the form of a nonlinear hyperbolic network, for which no generalexistence results are available. The modeling background and the challenges relatedto the analysis of the solutions will be presented. An application to the study of themechanical properties of the currently available coronary stents on the US marketwill be shown.This talk will be accessible to a wide scientific audience.Collaborators include: Josip Tambaca (University of Zagreb, Croatia), Ando Mikelic(University of Lyon 1, France), Dr. David Paniagua (Texas Heart Institute), and Dr.Stephen Little (Methodist Hospital in Houston).