Many problems in Geometry, Physics and Biology are described by nonlinear partial differential equations of second order or four order. In this talk I shall mainly address the blow-up phenomenon in a class of fourth order equations from conformal geometry and some Liouville systems from Physics and Ecology. There are some challenging open problems related to these equations and I will report the recent progress on these problems in my joint works with Gilbert Weinstein and Chang-shou Lin.
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