Georgia Institute of Technology College of Sciences

I will discuss regularity of fully nonlinear elliptic equations when the usual uniform upper bound on the ellipticity is replaced by bound on its $L^d$ norm, where $d$ is the dimension of the ambient space. Our estimates refine the classical theory and require several new ideas that we believe are of independent interest. As an application, we prove homogenization for a class of stationary ergodic strictly elliptic equations.

We study the nonparametric regression model (X1 , Y1 ), ...(Xn , Yn ) , where (Xi )i≥1 is the deterministic design and (Yi )i≥1 is a sequence of real random variables. Assume that the density of Yi is known and can be written as g (., f (Xi )) , which depends on a regression function f at the point Xi . The function f is assumed smooth, i.e. belonging to a Hoelder ball or a Nikol’ski ball. The aim is to estimate the regression function from the observations for two error risks (pointwise and global estimations) and to find the optimal estimator (in the sense of rates of convergence) for each density g . We are particularly interested in the study of irregular models, i.e. when the Fisher information does not exist (for example, when the density g is discontinuous like the uniform density). In this case, the rate of convergence can be improved with the use of nolinear estimators like Maximum likelihood or bayesian estimators. We use the locally parametric approach to construct a new local version of bayesian estimators. Under some conditions on the likelihood of the model, we propose an adaptive procedure based on the so-called Lepski’s method (adaptive selection of the bandwidth) which allows us to construct an optimal adaptive bayesian estimator. We apply this theory to several models like multiplicative uniform model, shifted exponential model, alpha model, inhomogeous Poisson model and Gaussian model

Multiscale numerical methods seek to compute approximate solutions to physical problems at a reduced computational cost compared to direct numerical simulations. This talk will cover two methods which have a fine scale atomistic model that couples to a coarse scale continuum approximation. The quasicontinuum method directly couples a continuum approximation to an atomistic model to create a coherent model for computing deformed configurations of crystalline lattices at zero temperature. The details of the interface between these two models greatly affects the model properties, and we will discuss the interface consistency, material stability, and error for energy-based and force-based quasicontinuum variants along with the implications for algorithm selection. In the case of crystalline lattices at zero temperature, the constitutive law between stress and strain is computed using the Cauchy-Born rule (the lattice deformation is locally linear and equal to the gradient). For the case of complex fluids, computing the stress-strain relation using a molecular model is more challenging since imposing a strain requires forcing the fluid out of equilibrium, the subject of nonequilibrium molecular dynamics. I will describe the derivation of a stochastic model for the simulation of a molecular system at a given strain rate and temperature.

Waterborne diseases cause over 3.5 million deaths annually, with cholera alone responsible for 3-5 million cases/year and over 100,000 deaths/year. Many waterborne diseases exhibit multiple characteristic timescales or pathways of infection, which can be modeled as direct and indirect transmission. A major public health issue for waterborne diseases involves understanding the modes of transmission in order to improve control and prevention strategies. One question of interest is: given data for an outbreak, can we determine the role and relative importance of direct vs. environmental/waterborne routes of transmission? We examine these issues by exploring the identifiability and parameter estimation of a differential equation model of waterborne disease transmission dynamics. We use a novel differential algebra approach together with several numerical approaches to examine the theoretical and practical identifiability of a waterborne disease model and establish if it is possible to determine the transmission rates from outbreak case data (i.e. whether the transmission rates are identifiable). Our results show that both direct and environmental transmission routes are identifiable, though they become practically unidentifiable with fast water dynamics. Adding measurements of pathogen shedding or water concentration can improve identifiability and allow more accurate estimation of waterborne transmission parameters, as well as the basic reproduction number. Parameter estimation for a recent outbreak in Angola suggests that both transmission routes are needed to explain the observed cholera dynamics. I will also discuss some ongoing applications to the current cholera outbreak in Haiti.