### Computational hemodynamics for Computer Aided Clinical Trials: looking at the theory, struggling with the practice

- Series
- Applied and Computational Mathematics Seminar
- Time
- Monday, September 25, 2017 - 13:55 for 1 hour (actually 50 minutes)
- Location
- Skiles 005
- Speaker
- Professor Alessandro Veneziani – Emory Department of Mathematics and Computer Science

When we get to the point of including the huge and relevant experience of
finite element fluid modeling collected in over 25 years of experience in the treatment of
cardiovascular diseases, the risk of getting “lost in translation” is real. The most important issues
are the reliability that we need to guarantee to provide a trustworthy decision support to clinicians;
the efficiency we need to guarantee to fit into the demand coming from a large volume of patients
in Computer Aided Clinical Trials as well as short timelines required by special
circumstances (emergency) in Surgical Planning.
In this talk, we will report on some recent activities taken at Emory to
make this transition possible. Reliability requirements call for an appropriate integration of
measurements and numerical models, as well as for uncertainty quantification. In particular, image and data
processing are critical to feeding mathematical models. However, there are several challenges still
open, e.g. in simulating blood flow in patient-specific arteries after stent deployment; or in
assessing the correct boundary data set to be prescribed in complex vascular districts. The gap between
theory, in this case, is apparent and good simulation and assimilation practices in finite elements
for clinical hemodynamics need to be drawn. The talk will cover these topics.
For computational efficiency, we will cover some numerical techniques currently in use for coronary
blood flow, like the Hierarchical Model Reduction or efficient methods for
coping with turbulence in aortic flows. As Clinical Trials are currently one of the most important sources of
information for medical research and practice, we envision that the suitable achievement of reliability and
efficiency requirements will make Computer Aided Clinical Trials (specifically with a strong
Finite-Elements-in-Fluids component) an important source of information with a significant impact on the
quality of healthcare. This is a joint work with the scholars and students of the Emory Center for
Mathematics and Computing in Medicine (E(CM)2), the Emory Biomech Core Lab (Don Giddens and Habib Samady), the Beta-Lab at the University of Pavia (F. Auricchio ). This work is supported by the US National
Science Foundation, Projects DMS 1419060, 1412963 1620406, Fondazione Cariplo, Abbott
Vascular Inc., and the XSEDE Consortium.