Counting Single Cut-or-Join Scenarios
- Series
- Combinatorics Seminar
- Time
- Friday, November 20, 2015 - 15:00 for 1 hour (actually 50 minutes)
- Location
- Skiles 006
- Speaker
- Heather Smith – Georgia Tech – heather.smith@math.gatech.edu
Represent a genome with an edge-labelled, directed graph
having maximum total degree two. We explore a number of questions
regarding genome rearrangement, a common mode of molecular evolution. In
the single cut-or-join model for genome rearrangement, a genome can
mutate in one of two ways at any given time: a cut divides a degree two
vertex into two degree one vertices while a join merges two degree one
vertices into one degree two vertex.
Fix a set of genomes, each having the same set of edge labels. The
number of ways for one genome to mutate into another can be computed in
polynomial time. The number of medians can also be computed in
polynomial time. While single cut-or-join is, computationally, the
simplest mathematical model for genome rearrangement, determining the
number of most parsimonious median scenarios remains #P-complete. We
will discuss these and other complexity results that arose from an
abstraction of this problem. [This is joint work with Istvan Miklos.]