Georgia Institute of Technology College of Sciences

Growth control establishes organism size, requiring mechanisms to sense and adjust growth. Studies of single cells revealed that size homeostasis uses distinct control methods: Size, Timer, and Adder. In multicellular organisms, mechanisms that regulate single cell growth must integrate control across organs and tissues during development to generate adult size and shape. We leveraged the roundworm Caenorhabditis elegans as a scalable and tractable model to collect precise growth measurements of thousands of individuals, measure feeding behavior, and quantify changes in animal size and shape. Using quantitative measurements and mathematical modeling, we propose two models of physical mechanisms by which C. elegans can control growth. First, constraints on cuticle stretch generate mechanical signals through which animals sense body size and initiate larval-stage transitions. Second, mechanical control of food intake drives growth rate within larval stages. These results suggest how physical constraints control developmental timing and growth rate in C. elegans.

https://www.biorxiv.org/content/10.1101/2021.04.01.438121v2

Recording link: https://bluejeans.com/s/9NyLSfq4tGD

The complex connectivity structure unique to the brain network is believed to underlie its robust and efficient coding capability. One of many unique features of the mammalian brain network is its spatial embedding and hierarchical organization. I will discuss effects of these structural characteristics on network dynamics as well as their computational implications with a focus on the flexibility between modular and global computations and predictive coding.  

Since Jones introduced his knot polynomial using representation theory, there has been a wide variety of invariants defined this way, e.g., HOMFLY-PT and Reshetikhin-Turaev. Recently, through the work of Bonahon-Wong and Constantino-Le, some of these invariants are reinterpreted as quantum matrices. In this talk, we will review the history of these representation theoretical knot invariants. Then we will discuss one particular connection to the quantum special linear group.

Motivated by toric geometry, Maclagan-Smith defined the multigraded Castelnuovo-Mumford regularity for sheaves on a simplicial toric variety. While this definition reduces to the usual definition on a projective space, other descriptions of regularity in terms of the Betti numbers, local cohomology, or resolutions of truncations of the corresponding graded module proven by Eisenbud and Goto are no longer equivalent. I will discuss recent joint work with Lauren Cranton Heller and Juliette Bruce on generalizing Eisenbud-Goto's conditions to the "easiest difficult" case, namely products of projective spaces, and our hopes and dreams for how to do the same for other toric varieties.

Breathers are temporally periodic and spatially localized solutions of evolutionary PDEs. They are known to exist for integrable PDEs such as the sine-Gordon equation, but are believed to be rare for general nonlinear PDEs. When the spatial dimension is equal to one, exchanging the roles of time and space variables (in the so-called spatial dynamics framework), breathers can be interpreted as homoclinic solutions to steady solutions and thus arising from the intersections of the stable and unstable manifolds of the steady states. In this talk, we shall study small breathers of the nonlinear Klein-Gordon equation generated in an unfolding bifurcation as a pair of eigenvalues collide at the original when a parameter (temporal frequency) varies. Due to the presence of the oscillatory modes, generally the finite dimensional stable and unstable manifolds do not intersect in the infinite dimensional phase space, but with an exponentially small splitting (relative to the amplitude of the breather) in this singular perturbation problem of multiple time scales. This splitting leads to the transversal intersection of the center-stable and center-unstable manifolds which produces small amplitude generalized breathers with exponentially small tails. Due to the exponential small splitting, classical perturbative techniques cannot be applied. We will explain how to obtain an asymptotic formula for the distance between the stable and unstable manifold of the steady solutions. This is a joint work of O. Gomide, M. Guardia, T. Seara, and C. Zeng.