Seminars and Colloquia by Series

Distinguishing mechanisms of immunopathology in COVID-19 using virtual patient cohorts

Series
Mathematical Biology Seminar
Time
Wednesday, January 19, 2022 - 10:00 for 1 hour (actually 50 minutes)
Location
ONLINE
Speaker
Morgan CraigUniversity of Montréal

Please Note: Meeting Link: https://bluejeans.com/426529046/8775

Two years after the beginning of the pandemic, we are still working to understand the mechanisms of immunopathology in COVID-19. Immune responses following SARS-CoV-2 infections are heterogeneous, and biomarkers of this variability remain to be elucidated. In collaboration with experimentalists and clinicians, we have deployed various mathematical and computational approaches to understand longitudinal immunological data from patients, and to generate new hypotheses about the factors determining COVID-19 severity and disease dynamics.
To answer foundational questions about immunopathology and heterogeneity in COVID-19, we have developed a multi-scale, mechanistic mathematical model of the immune response to SARS-CoV-2 that includes several innate and adaptive immune cells and their communication via signalling networks. By generating a population of virtual patients, we identified dysregulated rates of monocyte-to-macrophage differentiation that distinguishes disease severity in these in silico patients. Further, our results suggest that maximal IL-6 concentrations can be used as a predictive biomarker of CD8+ T cell lymphopenia. Using the same cohort of virtual patients, we have also studied the influence of variant on immunopathology by combining our model with data of intra-host viral evolution. We predicted that the combined effects of mutations affecting the spike proteins and interferon evasion on the severity of COVID-19 are mostly determined by the innate host immune response. Our approaches can be used to study the factors regulated immunopathology during SARS-CoV-2 infections, and represent a quantitative framework for the study of COVID-19 and other viral diseases.

Recording link: https://bluejeans.com/s/6CmKwHWWc2O

 

Long-time dynamics of dispersive equations

Series
Job Candidate Talk
Time
Tuesday, January 18, 2022 - 11:00 for 1 hour (actually 50 minutes)
Location
ONLINE
Speaker
Gong ChenUniversity of Toronto

Please Note: https://bluejeans.com/910698769/4854

Through the pioneering numerical computations of Fermi-Pasta-Ulam (mid 50s) and Kruskal-Zabusky (mid 60s) it was observed that nonlinear equations modeling wave propagation asymptotically decompose as a superposition of “traveling waves” and “radiation”. Since then, it has been a widely believed (and supported by extensive numerics) that “coherent structures” together with radiations describe the long-time asymptotic behavior of generic solutions to nonlinear dispersive equations. This belief has come to be known as the “soliton resolution conjecture”.  Roughly speaking it tells that, asymptotically in time, the evolution of generic solutions decouples as a sum of modulated solitary waves and a radiation term that disperses. This remarkable claim establishes a drastic “simplification” to the complex, long-time dynamics of general solutions. It remains an open problem to rigorously show such a description for most dispersive equations.  After an informal introduction to dispersive equations, I will survey some of my recent results towards understanding the long-time behavior of dispersive waves and the soliton resolution using techniques from both partial differential equations and inverse scattering transforms.

Talk cancelled

Series
Time
Tuesday, January 18, 2022 - 11:00 for
Location
Speaker

Simplicity and Optimality in Multi-Item Auctions

Series
ACO Student Seminar
Time
Friday, January 14, 2022 - 13:00 for 1 hour (actually 50 minutes)
Location
ONLINE
Speaker
Divyarthi MohanTel Aviv University

Please Note: Link: https://bluejeans.com/520769740/3630

Designing mechanisms to maximize revenue is a fundamental problem in mathematical economics and has various applications like online ad auctions and spectrum auctions. Unfortunately, optimal auctions for selling multiple items can be unreasonably complex and computationally intractable. In this talk, we consider a revenue-maximizing seller with n items facing a single unit-demand buyer. Our work shows that simple mechanisms can achieve almost optimal revenue. We approached the tradeoffs of simplicity formally through the lens of computation and menu size. Our main result provides a mechanism that gets a (1 − ε)-approximation to the optimal revenue in time quasi-polynomial in n and has quasi polynomial (symmetric) menu complexity. 

 

Joint work with Pravesh Kothari, Ariel Schvartzman, Sahil Singla, and Matt Weinberg.

Phase transitions in soft random geometric graphs

Series
Stochastics Seminar
Time
Thursday, January 13, 2022 - 15:30 for 1 hour (actually 50 minutes)
Location
https://bluejeans.com/257822708/6700
Speaker
Suqi LiuPrinceton University

Random graphs with latent geometric structure, where the edges are generated depending on some hidden random vectors, find broad applications in the real world, including social networks, wireless communications, and biological networks. As a first step to understand these models, the question of when they are different from random graphs with independent edges, i.e., Erd\H{o}s--R\'enyi graphs, has been studied recently. It was shown that geometry in these graphs is lost when the dimension of the latent space becomes large. In this talk, we focus on the case when there exist different notions of noise in the geometric graphs, and we show that there is a trade-off between dimensionality and noise in detecting geometry in the random graphs.

Turbulent Weak Solutions of the 3D Euler Equations

Series
Job Candidate Talk
Time
Thursday, January 13, 2022 - 11:00 for 1 hour (actually 50 minutes)
Location
ONLINE
Speaker
Matthew NovackIAS

Meeting link: https://bluejeans.com/912860268/9947

The Navier-Stokes and Euler equations are the fundamental models for describing viscous and inviscid fluids, respectively. Based on ideas which date back to Kolmogorov and Onsager, solutions to these equations are expected to dissipate energy, which in turn suggests that such solutions are somewhat rough and thus only weak solutions. At these low regularity levels, however, one may construct wild weak solutions using convex integration methods. In this talk, I will discuss the motivation and methodology behind joint work with Tristan Buckmaster, Nader Masmoudi, and Vlad Vicol in which we construct wild solutions to the Euler equations which deviate from the predictions of Kolmogorov's classical K41 phenomenological theory of turbulence.

Sharp bounds for the number of regions of maxout networks and vertices of Minkowski sums

Series
Algebra Seminar
Time
Tuesday, January 11, 2022 - 12:00 for 1 hour (actually 50 minutes)
Location
Skiles 006
Speaker
Yue RenDurham University

We present results on the number of linear regions of the functions that can be represented by artificial feedforward neural networks with maxout units. A rank-k maxout unit is a function computing the maximum of k linear functions. For networks with a single layer of maxout units, the linear regions correspond to the regions of an arrangement of tropical hypersurfaces and to the (upper) vertices of a Minkowski sum of polytopes. This is joint work with Guido Montufar and Leon Zhang.

Thresholds

Series
Job Candidate Talk
Time
Wednesday, December 15, 2021 - 11:00 for 1 hour (actually 50 minutes)
Location
https://bluejeans.com/487699041/8823
Speaker
Jinyoung ParkStanford University

Thresholds for increasing properties of random structures are a central concern in probabilistic combinatorics and related areas. In 2006, Kahn and Kalai conjectured that for any nontrivial increasing property on a finite set, its threshold is never far from its "expectation-threshold," which is a natural (and often easy to calculate) lower bound on the threshold. In this talk, I will first introduce the Kahn-Kalai Conjecture with some motivating examples and then talk about the recent resolution of a fractional version of the Kahn-Kalai Conjecture due to Frankston, Kahn, Narayanan, and myself. Some follow-up work, along with open questions, will also be discussed.

A proof of the Erdős–Faber–Lovász conjecture and related problems

Series
Graph Theory Seminar
Time
Tuesday, December 14, 2021 - 11:00 for 1 hour (actually 50 minutes)
Location
ONLINE
Speaker
Abhishek MethukuUniversity of Birmingham

Please Note: Note the unusual time!

The famous Erdős–Faber–Lovász conjecture (posed in 1972) states that the chromatic index of any linear hypergraph on n vertices is at most n. In this talk, I will briefly sketch a proof of this conjecture for every large n. If time permits, I will also talk about our solution to a problem of Erdős from 1977 about chromatic index of hypergraphs with bounded codegree. Joint work with D. Kang, T. Kelly, D.Kuhn and D. Osthus.

Regularity lemma: discrete and continuous perspectives

Series
Job Candidate Talk
Time
Monday, December 13, 2021 - 11:00 for 1 hour (actually 50 minutes)
Location
https://bluejeans.com/774516207/3993
Speaker
Fan WeiPrinceton University

Szemerédi's regularity lemma is a game-changer in extremal combinatorics and provides a global perspective to study large combinatorial objects. It has connections to number theory, discrete geometry, and theoretical computer science. One of its classical applications, the removal lemma, is the essence for many property testing problems, an active field in theoretical computer science. Unfortunately, the bound on the sample size from the regularity method typically is either not explicit or enormous. For testing natural permutation properties, we show one can avoid the regularity proof and yield a tester with polynomial sample size. For graphs, we prove a stronger, "L_\infty'' version of the graph removal lemma, where we conjecture that the essence of this new removal lemma for cliques is indeed the regularity-type proof. The analytic interpretation of the regularity lemma also plays an important role in graph limits, a recently developed powerful theory in studying graphs from a continuous perspective. Based on graph limits, we developed a method combining with both analytic and spectral methods, to answer and make advances towards some famous conjectures on a common theme in extremal combinatorics: when does randomness give nearly optimal bounds? 

These works are based on joint works with Jacob Fox, Dan Kral',  Jonathan Noel, Sergey Norin, and Jan Volec.

 

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