Georgia Institute of Technology School of Mathematics | Georgia Institute of Technology | Atlanta, GA

Constriction of blood vessels in the extremities due to traumatic injury to halt excessive blood loss or resulting from pathologic occlusion can cause considerable damage to the surrounding tissues with significant morbidity and mortality. Optimal healing of damaged tissue relies on the precise balance of pro-inflammatory and pro-healing processes of innate inflammation. In this talk, we will present a discrete multiscale mathematical model that spans the tissue and intracellular scales, and captures the consequences of targeting various regulatory components. We take advantage of the canalization properties of some of the functions, which is a type of hierarchical clustering of the inputs, and use it as control to steer the system away from a faulty attractor and understand better the regulatory relations that govern the system dynamics.EDIT: CANCELLED

Thermodynamics provides a robust conceptual framework and set of laws that govern the exchange of energy and matter. Although these laws were originally articulated for macroscopic objects, it is hard to deny that nanoscale systems, as well, often exhibit “thermodynamic-like” behavior. To what extent can the venerable laws of thermodynamics be scaled down to apply to individual microscopic systems, and what new features emerge at the nanoscale? I will review recent progress toward answering these questions, with a focus on the second law of thermodynamics. I will argue that the inequalities ordinarily used to express the second law can be replaced by stronger equalities, known as fluctuation relations, which relate equilibrium properties to far-from-equilibrium fluctuations. The discovery and experimental validation of these relations has stimulated interest in the feedback control of small systems, the closely related Maxwell demon paradox, and the interpretation of the thermodynamic arrow of time. These developments have led to new tools for the analysis of non-equilibrium experiments and simulations, and they have refined our understanding of irreversibility and the second law. Bio Chris Jarzynski received an AB degree in physics from Princeton University in 1987, and a PhD in physics from the University of California, Berkeley in 1994. After postdoctoral positions at the University of Washington in Seattle and at Los Alamos National Laboratory in New Mexico, he became a staff member in the Theoretical Division at Los Alamos. In 2006, he moved to the University of Maryland, College Park, where he is now a Distinguished University Professor in the Department of Chemistry and Biochemistry, with joint appointments in the Institute for Physical Science and Technology and the Department of Physics. His research is primarily in the area of nonequilibrium statistical physics, where he has contributed to an understanding of how the laws of thermodynamics apply to nanoscale systems. He has been the recipient of a Fulbright Fellowship, the 2005 Sackler Prize in the Physical Sciences, and the 2019 Lars Onsager Prize in Theoretical Statistical Physics. He is a Fellow of the American Physical Society and the American Academy of Arts and Sciences. Contact: Professor Jennifer Curtis Email: jennifer.curtis@physics.gatech.edu

I will discuss chaos in quantum many-body systems, specifically how it is relates to thermalization and how it fails in many-body localized states. I will conjecture a new universal form for the spreading of chaos in local systems, and discuss evidence for the conjecture from a variety of sources including new large-scale simulations of quantum dynamics of spin chains.