### Algebraic Systems Biology, Model Selection and Parameter Estimation

- Series
- Algebra Seminar
- Time
- Tuesday, May 31, 2016 - 11:05 for 1 hour (actually 50 minutes)
- Location
- Skiles 006
- Speaker
- Elizabeth Gross – San Jose State University

Systems biology focuses on modeling complex biological systems, such as
metabolic and cell signaling networks. These biological networks are
modeled with polynomial dynamical systems. Analyzing these systems at
steady-state results in algebraic varieties that live in
high-dimensional spaces. By understanding these varieties, we can
provide insight into the behavior of the models. Furthermore, this
algebro-geometric framework yields techniques for model selection and
parameter estimation that can circumvent challenges such as limited or
noisy data. In this talk, we will introduce biochemical reaction
networks and their resulting steady-state varieties. In addition, we
will discuss the questions asked by modelers and their corresponding
geometric interpretation, particularly in regards to model selection and
parameter estimation.