Georgia Institute of Technology College of Sciences

The term cancer covers a multitude of bodily diseases, broadly categorized by having cells which do not behave normally. Cancer cells can arise from any type of cell in the body; cancers can grow in or around any tissue or organ making the disease highly complex. My research is focused on understanding the specific mechanisms that occur in the tumour microenvironment via mathematical and computational modelling. In this talk I shall present a 3D individual-based force-based model for tumour growth and development in which we simulate  the behavior of, and spatio-temporal interactions between, cells, extracellular matrix fibres and blood vessels. Each agent is fully realised, for example, cells are described as viscoelastic sphere with radius and centre given within the off-lattice model. Interactions are primarily governed by mechanical forces between elements. However, as well as the mechanical interactions we also consider chemical interactions, by coupling the code to a finite element solver to model the diffusion of oxygen from blood vessels to cells, as well as intercellular aspects such as cell phenotypes. 

I’ll describe various aspects of my joint work with Oliver Lorscheid on the foundation of a matroid.

Symmetric unions are an interesting class of knots. Although they have not been studied much for their own sake, they frequently appear in the literature. One such instance regards the question of whether there is a nontrivial knot with trivial Jones polynomial. In my talk, I will describe a class of symmetric unions, constructed by Tanaka, such that if any are amphichiral, they would have trivial Jones polynomial. Then I will show how such a knot not only answers the above question but also gives rise to a counterexample to the Cosmetic Surgery Conjecture. However, I will prove that such a knot is in fact trivial and hence cannot be used to answer any of these questions. Finally, I will discuss how the arguments that go into this proof can be generalized to study amphichiral symmetric unions.

Breathers are temporally periodic and spatially localized solutions of evolutionary PDEs. They are known to exist for integrable PDEs such as the sine-Gordon equation, but are believed to be rare for general nonlinear PDEs. When the spatial dimension is equal to one, exchanging the roles of time and space variables (in the so-called spatial dynamics framework), breathers can be interpreted as homoclinic solutions to steady solutions and thus arising from the intersections of the stable and unstable manifolds of the steady states. In this talk, we shall study small breathers of the nonlinear Klein-Gordon equation generated in an unfolding bifurcation as a pair of eigenvalues collide at the original when a parameter (temporal frequency) varies. Due to the presence of the oscillatory modes, generally the finite dimensional stable and unstable manifolds do not intersect in the infinite dimensional phase space, but with an exponentially small splitting (relative to the amplitude of the breather) in this singular perturbation problem of multiple time scales. This splitting leads to the transversal intersection of the center-stable and center-unstable manifolds which produces small amplitude generalized breathers with exponentially small tails. Due to the exponential small splitting, classical perturbative techniques cannot be applied. We will explain how to obtain an asymptotic formula for the distance between the stable and unstable manifold of the steady solutions. This is a joint work of O. Gomide, M. Guardia, T. Seara, and C. Zeng.