A major challenge in clinical and biomedical research is on translating in-vitro and in- vivo model findings to humans. Translation success rate of all new compounds going through different clinical trial phases is generally about 10%. (i) This field is challenged by a lack of robust methods that can be used to translate model findings to humans (or interpret preclinical finds to accurately design successful patient regimens), hence providing a platform to evaluate a plethora of agents before they are channeled in clinical trials. Using set theory principles of mapping morphisms, we recently developed a novel translational framework that can faithfully map experimental results to clinical patient results. This talk will demonstrate how this method was used to predict outcomes of anti-TB drug clinical trials. (ii) Translation failure is deeply rooted in the dissimilarities between humans and experimental models used; wide pathogen isolates variation, patient population genetic diversities and geographic heterogeneities. In TB, bacteria phenotypic heterogeneity shapes differential antibiotic susceptibility patterns in patients. This talk will also demonstrate the application of dynamical systems in Systems Biology to model (a) gene regulatory networks and how gene programs influence Mycobacterium tuberculosis bacteria metabolic/phenotypic plasticity. (b) And then illustrate how different bacteria phenotypic subpopulations influence treatment outcomes and the translation of preclinical TB therapeutic regimens. In general, this talk will strongly showcase how mathematical modeling can be used to critically analyze experimental and patient data.
Strong edge coloring of a graph $G$ is a coloring of the edges of the graph such that each color class is an induced subgraph. The strong chromatic index of $G$ is the smallest number $k$ such that $G$ has a $k$-strong edge coloring. Erdős and Nešetřil conjecture that the strong chromatic index of a graph of max degree $\Delta$ is at most $5\Delta^2/4$ if $\Delta$ is even and $(5\Delta^2-2\Delta + 1)/4$ if $\Delta$ is odd. It is known for $\Delta=3$ that the conjecture holds, and in this talk I will present part of Anderson's proof that the strong chromatic index of a subcubic planar graph is at most $10$
We study delocalization properties of null vectors and eigenvectors of matrices with i.i.d. subgaussian entries. Such properties describe quantitatively how "flat" is a vector and confirm one of the universality conjectures stating that distributions of eigenvectors of many classes of random matrices are close to the uniform distribution on the unit sphere. In particular, we get lower bounds on the smallest coordinates of eigenvectors, which are optimal as the case of Gaussian matrices shows. The talk is based on the joint work with Konstantin Tikhomirov.
