Georgia Institute of Technology College of Sciences

I will present joint work with Elena Kosygina and Ofer Zeitouni in which we prove the homogenization of a class of one-dimensional viscous Hamilton-Jacobi equations with random Hamiltonians that are nonconvex in the gradient variable. Due to the special form of the Hamiltonians, the solutions of these PDEs with linear initial conditions have representations involving exponential expectations of controlled Brownian motion in a random potential. The effective Hamiltonian is the asymptotic rate of growth of these exponential expectations as time goes to infinity and is explicit in terms of the tilted free energy of (uncontrolled) Brownian motion in a random potential. The proof involves large deviations, construction of correctors which lead to exponential martingales, and identification of asymptotically optimal policies.

A major challenge in clinical and biomedical research is on translating in-vitro and in- vivo model findings to humans. Translation success rate of all new compounds going through different clinical trial phases is generally about 10%. (i) This field is challenged by a lack of robust methods that can be used to translate model findings to humans (or interpret preclinical finds to accurately design successful patient regimens), hence providing a platform to evaluate a plethora of agents before they are channeled in clinical trials. Using set theory principles of mapping morphisms, we recently developed a novel translational framework that can faithfully map experimental results to clinical patient results. This talk will demonstrate how this method was used to predict outcomes of anti-TB drug clinical trials. (ii) Translation failure is deeply rooted in the dissimilarities between humans and experimental models used; wide pathogen isolates variation, patient population genetic diversities and geographic heterogeneities. In TB, bacteria phenotypic heterogeneity shapes differential antibiotic susceptibility patterns in patients. This talk will also demonstrate the application of dynamical systems in Systems Biology to model (a) gene regulatory networks and how gene programs influence Mycobacterium tuberculosis bacteria metabolic/phenotypic plasticity. (b) And then illustrate how different bacteria phenotypic subpopulations influence treatment outcomes and the translation of preclinical TB therapeutic regimens. In general, this talk will strongly showcase how mathematical modeling can be used to critically analyze experimental and patient data.

Neural networks with a large number of parameters admit a mean-field description, which has recently served as a theoretical explanation for the favorable training properties of "overparameterized" models. In this regime, gradient descent obeys a deterministic partial differential equation (PDE) that converges to a globally optimal solution for networks with a single hidden layer under appropriate assumptions. In this talk, we propose a non-local mass transport dynamics that leads to a modified PDE with the same minimizer. We implement this non-local dynamics as a stochastic neuronal birth-death process and we prove that it accelerates the rate of convergence in the mean-field limit. We subsequently realize this PDE with two classes of numerical schemes that converge to the mean-field equation, each of which can easily be implemented for neural networks with finite numbers of parameters. We illustrate our algorithms with two models to provide intuition for the mechanism through which convergence is accelerated. Joint work with G. Rotskoff (NYU), S. Jelassi (Princeton) and E. Vanden-Eijnden (NYU).

In this series of (3-5) lectures, I will talk about different aspects of a class of contact 3-manifolds for which geometry, dynamics and topology interact subtly and beautifully. The talks are intended to include short surveys on "compatibility", "Anosovity" and "Conley-Zehnder indices". The goal is to use the theory of Contact Dynamics to show that conformally Anosov contact 3-manifolds (in particular, contact 3-manifolds with negative α-sectional curvature) are universally tight, irreducible and do not admit a Liouville cobordism to the tight 3-sphere.