Georgia Institute of Technology College of Sciences

This will be a continuation of the previous talk by this title. Specifically, this will be a presentation of the classical result on the existence of three closed nonselfintersecting geodesics on surfaces diffeomorphic to the sphere. It will be accessible to anyone interested in topology and geometry.

We prove that a smooth compact submanifold of codimension $2$ immersed in $R^n$, $n>2$, bounds at most finitely many topologically distinct compact nonnegatively curved hypersurfaces. This settles a question of Guan and Spruck related to a problem of Yau. Analogous results for complete fillings of arbitrary Riemannian submanifolds are obtained as well. On the other hand, we show that these finiteness theorems may not hold if the codimension is too high, or the prescribed boundary is not sufficiently regular. Our proofs employ, among other methods, a relative version of Nash's isometric embedding theorem, and the theory of Alexandrov spaces with curvature bounded below, including the compactness and stability theorems of Gromov and Perelman. These results consist of joint works with Stephanie Alexander and Jeremy Wong, and Robert Greene.

Chronic HBV infection affects 350 million people and can lead to death through cirrhosis-induced liver failure or hepatocellular carcinoma. We present the rich dynamics of two recent models of HBV infection with logistic hepatocyte growth and a standard incidence function governing viral infection. One of these models also incorporates an explicit time delay in virus production. All model parameters can be estimated from biological data. We simulate a course of lamivudine therapy and find that the models give good agreement with clinical data. Previous models considering constant hepatocyte growth have permitted only two dynamical possibilities: convergence to a virus free or an endemic steady state. Our models admit periodic solutions. Minimum hepatocyte populations are very small in the periodic orbit, and such a state likely represents acute liver failure. Therefore, the often sudden onset of liver failure in chronic HBV patients can be explained as a switch in stability caused by the gradual evolution of parameters representing the disease state.

In this talk I will give a purely combinatorial description of Knot Floer Homology for knots in the three-sphere (Manolescu-Ozsvath-Szabo- Thurston). In this homology there is a naturally associated invariant for transverse knots. This invariant gives a combinatorial but still an effective way to distinguish transverse knots (Ng-Ozsvath-Thurston). Moreover it leads to the construction of an infinite family of non-transversely simple knot-types (Vertesi).