Braid groups
- Series
- Research Horizons Seminar
- Time
- Wednesday, February 27, 2019 - 12:05 for 1 hour (actually 50 minutes)
- Location
- Skiles 006
- Speaker
- Dan Margalit – Georgia Tech
Inference of evolutionary dynamics of heterogeneous cancer and viral populations Abstract: Genetic diversity of cancer cell populations and intra-host viral populations is one of the major factors influencing disease progression and treatment outcome. However, evolutionary dynamics of such populations remain poorly understood. Quantification of selection is a key step to understanding evolutionary mechanisms driving cancer and viral diseases. We will introduce a mathematical model and an algorithmic framework for inference of fitness landscapes of heterogeneous populations from genomic data. It is based on a maximal likelihood approach, whose objective is to estimate a vector of clone/strain fitnesses which better fits the observed tumor phylogeny, observed population structure and the dynamical system describing evolution of the population as a branching process. We will discuss our approach to solve the problem by transforming the original continuous maximum likelihood problem into a discrete optimization problem, which could be considered as a variant of scheduling problem with precedent constraints and with non-linear cumulative cost function.
Wiener-Hopf factorization (WHf) encompasses several important results in probability and stochastic processes, as well as in operator theory. The importance of the WHf stems not only from its theoretical appeal, manifested, in part, through probabilistic interpretation of analytical results, but also from its practical applications in a wide range of fields, such as fluctuation theory, insurance and finance. The various existing forms of the WHf for Markov chains, strong Markov processes, Levy processes, and Markov additive process, have been obtained only in the time-homogeneous case. However, there are abundant real life dynamical systems that are modeled in terms of time-inhomogenous processes, and yet the corresponding Wiener-Hopf factorization theory is not available for this important class of models. In this talk, I will first provide a survey on the development of Wiener-Hopf factorization for time-homogeneous Markov chains, Levy processes, and Markov additive processes. Then, I will discuss our recent work on WHf for time-inhomogensous Markov chains. To the best of our knowledge, this study is the first attempt to investigate the WHf for time-inhomogeneous Markov processes.