Georgia Institute of Technology College of Sciences

Understanding the folding of RNA sequences into three-dimensional structures is one of the fundamental challenges in molecular biology. In this talk, we focus on understanding how an RNA viral genome can fold into the dodecahedral cage known from experimental data. Using strings and trees as a combinatorial model of RNA folding, we give mathematical results which yield insight into RNA structure formation and suggest new directions in viral capsid assembly. We also illustrate how the interaction between discrete mathematics and molecular biology motivates new combinatorial theorems as well as advancing biomedical applications.

In the 60s, Grothendieck had the remarkable idea of introducing a new kind of topology where open coverings of X are no longer collections of subsets of X, but rather certain maps from other spaces to X.  I will give some examples to show why this is reasonable and what one can do with it.

Why do parasites cause disease? Theory has shown that natural selection could select for virulent parasites if virulence is correlated with between-host parasite transmission. Because ecological conditions may affect virulence and transmission, theory further predicts that adaptive levels of virulence depend on the specific environment in which hosts and parasites interact. To test these predictions in a natural system, we study monarch butterflies (Danaus plexippus) and their protozoan parasite (Ophryocystis elektroscirrha). Our studies have shown that more virulent parasites obtain greater between-host transmission, and that parasites with intermediate levels of virulence obtain highest fitness. The average virulence of wild parasite isolates falls closely to this optimum level, providing additional support that virulence can evolve as a consequence of natural selection operating on parasite transmission. Our studies have also shown that parasites from geographically separated populations differ in their virulence, suggesting that population-specific ecological factors shape adaptive levels of virulence. One important ecological factor is the monarch larval host plants in the milkweed family. Monarch populations differ in the milkweed species they harbor, and experiments have shown that milkweeds can alter parasite virulence. Our running hypothesis is that plant availability shapes adaptive levels of parasite virulence in natural monarch populations. Testing this hypothesis will improve our understanding of why some parasites are more harmful than others, and will help with predicting the consequences of human actions on the evolution of disease.

We are going to continue explaining the proof of Seip's Interpolation Theorem for the Bergman Space. We are going to demonstrate the sufficiency of these conditions for a certain example. We then will show how to deduce the full theorem with appropriate modifications of the example.