Georgia Institute of Technology College of Sciences

If viewed realistically, models under consideration are always false. A consequence of model falseness is that for every data generating mechanism, there exists a sample size at which the model failure will become obvious. There are occasions when one will still want to use a false model, provided that it gives a parsimonious and powerful description of the generating mechanism. We introduced a model credibility index, from the point of view that the model is false. The model credibility index is defined as the maximum sample size at which samples from the model and those from the true data generating mechanism are nearly indistinguishable. Estimating the model credibility index is under the framework of subsampling, where a large data set is treated as our population, subsamples are generated from the population and compared with the model using various sample sizes. Exploring the asymptotic properties of the model credibility index is associated with the problem of estimating variance of U statistics. An unbiased estimator and a simple fix-up are proposed to estimate the U statistic variance.

The transportation problem can be formulated as the problem of finding the optimal way to transport a given measure into another with the same mass. In mathematics, there are at least two different but very important types of optimal transportation: Monge-Kantorovich problem and ramified transportation. In this talk, I will give a brief introduction to the theory of ramified optimal transportation. In terms of applied mathematics, optimal transport paths are used to model many "tree shaped" branching structures, which are commonly found in many living and nonliving systems. Trees, river channel networks, blood vessels, lungs, electrical power supply systems, draining and irrigation systems are just some examples. After briefly describing some basic properties (e.g. existence, regularity) as well as numerical simulation of optimal transport paths, I will use this theory to explain the dynamic formation of tree leaves. On the other hand, optimal transport paths provide excellent examples for studying geodesic problems in quasi-metric spaces, where the distance functions satisfied a relaxed triangle inequality: d(x,y) <= K(d(x,z)+d(z,y)). Then, I will introduce a new concept "dimensional distance" on the space of probability measures. With respect to this new metric, the dimension of a probability measure is just the distance of the measure to any atomic measure. In particular, measures concentrated on self-similar fractals (e.g. Cantor set, fat Cantor sets) will be of great interest to us.

Mathematical models are used to study possible impact of drug treatment of infections with the human immunodeficiency virus type 1 (HIV-1) on the evolution of the pathogen. Treating HIV-infected patients with a combination of several antiretroviral drugs usually contributes to a substantial decline in viral load and an increase in CD4+ T cells. However, continuing viral replication in the presence of drug therapy can lead to the emergence of drug-resistant virus variants, which subsequently results in incomplete viral suppression and a greater risk of disease progression. As different types of drugs (e.g., reverse transcriptase inhibitors,protease inhibitors and entry inhibitors) help to reduce the HIV replication at different stages of the cell infection, infection-age-structured models are useful to more realistically model the effect of these drugs. The model analysis will be presented and the results are linked to the biological questions under investigation. By demonstrating how drug therapy may influence the within host viral fitness we show that while a higher treatment efficacy reduces the fitness of the drug-sensitive virus, it may provide a stronger selection force for drug-resistant viruses which allows for a wider range of resistant strains to invade.