Influence of Cellular Substructure on Gene Expression and Regulation
- Series
- Applied and Computational Mathematics Seminar
- Time
- Monday, April 12, 2010 - 13:00 for 1 hour (actually 50 minutes)
- Location
- Skiles 255
- Speaker
- Samuel Isaacson – Boston University Mathematics Dept.
We will give an overview of our recent work investigating the influence
of incorporating cellular substructure into stochastic
reaction-diffusion models of gene regulation and expression. Extensions
to the reaction-diffusion master equation that incorporate effects due
to the chromatin fiber matrix are introduced. These new mathematical
models are then used to study the role of nuclear substructure on the
motion of individual proteins and mRNAs within nuclei. We show for
certain distributions of binding sites that volume exclusion due to
chromatin may reduce the time needed for a regulatory protein to locate
a binding site.